
Martin Best is a brilliant surgeon who abruptly leaves his illustrious career in Boston to become the general practitioner in a quaint East Coast fishing village where he spent summers as a child. Unfortunately, Martin's blunt and borderline rude bedside manner rubs the quirky, needy locals the wrong way, and he quickly alienates the town, even though he's all they've got. Although Martin can expertly address any medical ailment or mystery in this idiosyncratic town, he's really just desperate to be left the hell alone. Instead, he keeps getting dragged right smack into the middle of their personal chaos, feuds and fantasies. What the locals don't know is that Martin's terse demeanor masks a debilitating new phobia and deep-seated psychological issues that prevent him from experiencing true intimacy with anyone. But tenacity is the creed of everyone in their small village, and the people who live there may be exactly what the doctor ordered.
On the eve of Port Wenn's annual blueberry festival, Martin treats a local man who has apparently become blue from eating too many blueberries; Martin is disturbed by Aunt Sarah's lack of attention to her health.
When Port Wenn puts on their annual "Blood Factory," celebrating the gory horror novel set there, Martin must contain his secret debilitating blood phobia when Louisa gets seriously ill and needs his help.