
"Without a Trace" is a fast-paced procedural drama about the Missing Persons Squad of the Federal Bureau of Investigation in New York City. The sole responsibility of the special task force is to find missing persons by applying advanced psychological profiling techniques to the evidence and decide whether the missing people have been abducted, murdered, committed suicide or simply run away. Members of the unit include supervisory agent Jack Malone (Anthony LaPaglia) and field agent Samantha "Sam" Spade (Poppy Montgomery).

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When a girl disappears on the way to school, the team analyzes videotapes she made with her best friend in hope of finding clues.
Malone and the team search for a woman who has disappeared from a hospital before being told about medical complications related to her pregnancy.
A desperate man continues to search for his missing son, even though Malone advises him the case is a lost cause.
The team searches for an airline stewardess (Heather Donahue) who vanished hours before her flight was scheduled to leave.