
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

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While Howard and Bernadette welcome their new baby into the world, Amy celebrates her own birthday with Sheldon.
Sheldon and Amy visit Penny and Leonard after the holidays and tell them about their terrible trip to Texas.
Penny thinks Leonard is taking her for granted and decides to go on a spa weekend with Amy; Wolowitz and Koothrappali try to fix a squeaky floorboard in the baby's room.
Sheldon tries to stay awake with an energy drink as the gang races to finish its government project on time; Penny and Amy attend a gathering at Bert the Geologist's house; Koothrappali learns Bernadette's true feelings about her pregnancy.