
World's Most Evil Killers delves straight into the stories of the world's most prolific killers. Each episode focuses on one notorious killer and features first-hand accounts of their behavior; such killers range from Fred and Rose West, Ed Gein, the Clown Killer, to the Milwaukee Cannibal. Accounts are also given by detectives who ran the cases, journalists who reported on them, relatives, experts on analysis, and sometimes even survivors.

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From October 1989 to April 1991, Wolfgang Schmidt murdered five women and an infant; the area where some of the crimes took place leads to a second moniker, "the Beast of Beelitz."
Arthur Shawcross, known as the Genesee River Killer, was a serial killer who murdered 11 women.
A terrifying killer snatches away the lives of four victims before being caught while trying to claim his fifth.
William Bonin is thought to have raped, tortured and murdered a minimum of twenty-one boys and young men.