
Growing up in racially segregated Birmingham, Alabama, during the 1960's, Rene and Mary Elizabeth manage to stick together despite community intolerance of "mixed" friendships. Many years later, following the death of her father, Rene returns home and reunites with Mary Elizabeth. The women realize that despite their career and family differences, they can help each other find happiness.
Rene and Mary Elizabeth attend their high-school reunion, reminiscing about their school's integration.
Rene represents a child on trial for murder; Collier makes M.E. quit her job; young Rene and M.E. experiment with alcohol.
Police discriminate against Rene; M.E. researches a corrupt city council; young Rene and M.E. witness the changing moods of their older brothers.
Rene becomes a "Big Sister"; M.E. appears on a talk show; young M.E. wants Rene to take advantage of Theresa.